British number one Andy Murray will face American world number 104 Tennys Sandgren in the first round of the US Open, while Johanna Konta will play Serbia’s Aleksandra Krunic.
Konta, whose opponent is ranked 77, could face Simona Halep in the quarter-finals, as she did at Wimbledon.
However, the Romanian world number two will have to overcome wildcard Maria Sharapova at the first hurdle.
Roger Federer and Rafael Nadal are seeded to meet in the men’s semi-final.
Third seed Federer will start against American youngster Francis Tiafoe and new world number one Nadal faces world number 84 Dusan Lajovic of Serbia.
British number two Kyle Edmund is up against Dutch veteran Robin Haase.
The women’s defending champion, Germany’s Angelique Kerber, will take on Naomi Osaka of Japan but Stan Wawrinka, who beat Novak Djokovic in last year’s final, is one of several high-profile absentees, including Djokovic.
Wimbledon champion and world number three Garbine Muguruza of Spain will play Varvara Lepchenko of the US.
Halep v Sharapova the tie of the opening round
Sharapova will play in a Grand Slam for the first time since the Australian Open in 2016, where she gave the positive drugs test that put her out of the game for 15 months.
The US Open is the first Slam to award Sharapova, a former champion, a wildcard to the main draw since she returned from her ban.
Sharapova and second seed Halep, one of the title favourites, have played six times, including in the French Open final in 2014, with the Russian winning every time.
Elsewhere, Great Britain’s Heather Watson, who has suffered six consecutive first-round losses at the US Open, will attempt to end that streak against France’s Alize Cornet.
Top women’s seed Karolina Pliskova meets Poland’s Magda Linette,
Kind draw for Murray
Murray will test out the hip that troubled him during Wimbledon. The Scot has not played a match since his quarter-final exit at SW19, losing the world number one ranking to Nadal.
Sandgren, 26, only made his Grand Slam debut at the French Open this year, losing in the first round.
The first seed Murray is scheduled to meet is Argentine Diego Schwartzman in round three, with the likes of David Ferrer, Lucas Pouille and Jo-Wilfried Tsonga waiting after that.
Cameron Norrie, British number five, reaches main draw
Cameron Norrie has booked his place in the main draw of the US Open with a 6-1 7-6 (7-5) win over Japan’s Go Soeda.
The British number five, ranked 226 in the world, had never played in Grand Slam qualifying before.
But he did not drop a set over three matches, beating Alexander Bublik, Sekou Bangoura and then Soeda.
The 22-year-old joins compatriots Andy Murray, Kyle Edmund, Aljaz Bedene, Johanna Konta and Heather Watson in the main draw.
Naomi Broady and Katie Boulter are due to play their final qualifiers later.
Norrie made his Grand Slam debut at Wimbledon, losing in the first round to Jo-Wilfried Tsonga.
The US Open gets under way at Flushing Meadows in New York on 28 August.